Piero di Lorenzo de' Medici (Feb 15, 1472 - Dec 28, 1500) also known as Piero the Unfortunate, is the eldest son of Lorenzo de' Medici and Clarice Orsini. He was the heir apparent to the Medici Bank, but blocked his protests and attempts of the first and second assassinations carried out by his father, which temporarily led to his disgrace in the eyes of his father. In the last episode, however, Lorenzo himself calls off the second assassination himself, and the two reconcile. Not shown in the series, he does become Lord of Florence for two years, but is exiled after a revolution for mishandling war with France, hence his nickname.
He is the older brother of Giovanni di Lorenzo de' Medici and Maddalena de' Medici and the cousin of Giulio de' Medici.